A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene
نویسندگان
چکیده
منابع مشابه
A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene.
NF1 inactivation occurs in specific human cancers, including juvenile myelomonocytic leukemia, an aggressive myeloproliferative disorder of childhood. However, evidence suggests that Nf1 loss alone does not cause leukemia. We therefore hypothesized that inactivation of the Nf1 tumor suppressor gene requires cooperating mutations to cause acute leukemia. To search for candidate genes that cooper...
متن کاملMYELOID NEOPLASIA A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene
1Masonic Cancer Center and Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis; 2Department of Hematology, Erasmus University Medical Centre, Rotterdam, The Netherlands; 3Department of Molecular Genetics and Microbiology, Center for Mammalian Genetics, University of Florida College of Medicine, Gainesville; and 4Department of Pediatrics, University of Cali...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis.
Intrinsic stress response pathways are frequently mobilized within tumor cells. The mediators of these adaptive mechanisms and how they contribute to carcinogenesis remain poorly understood. A striking example is heat shock factor 1 (HSF1), master transcriptional regulator of the heat shock response. Surprisingly, we found that loss of the tumor suppressor gene neurofibromatosis type 1 (Nf1) in...
متن کاملNF1 Tumor Suppressor Gene Function Narrowing the GAP
tumor suppressor gene, loss of heterozygosity (LOH) or Introduction “second-hit” somatic mutations in the inherited wildTumor suppressor genes are typically identified through type allele have been detected in some tumor types in their association with a familial cancer syndrome. As a NF1 patients (Xu et al., 1992; Legius et al., 1993; Shannon result, information regarding the normal function o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 2009
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2008-03-144436